Wellderly

Wellderly is a probiotic complex by SynBalance, specifically designed for elderly well-being.
Based on in-vitro rational and clinical trial, Wellderly provides relief from inflammatory symptoms, improves gastro-intestinal motility, restores healthy microbiota diversity and promotes body natural defenses.
A randomized, double blind, placebo control human clinical trial has involved 50 subjects which took the product for 28 days (T28) and were further evaluated after other 28 days of follow-up (T56). It was an easy to swallow delivery form containing 1B CFU/day/strain, meaning total 4B CFU/day. Patients were evaluated through a collection of daily questionnaire/ diary reporting inflammatory symptoms assessment, collection of stool , saliva samples and genomic analysis of stool for determination of microbiota composition in terms of phylum & genera (T0, T28 and T56).
Results revealed an improvement of anti-inflammatory & antioxidant activity through an increment of beta-defensin peptides during the treatment, as well as an increased salivary IgA and salivary total antioxidant capacity, showing a positive trend even after the end of the treatment (T56). In addition, a reduction of infections prevalence (either respiratory or gastrointestinal) and a shorter symptoms duration has been reported in the active group with respect to placebo.
Phylum & genera analysis showed a biodiversity restoration at gastrointestinal level, which reflects the overall positive response of the active group.