KeepCalm

KeepCalm is a probiotic complex by SynBalance, specifically designed for stress relief.
KeepCalm has been clinically tested in three different clinical trials targeting different high-stressed conditions. A proof-of-concept trial was conducted on 30 stressed students to evaluate KeepCalm (4B CFU/day) ability in improving stress-related parameters for 28 days. Results showed a significant improvement of short-term memory, attention and problem-solving flexibility with a better responsiveness with respect to the beginning. Moreover, positive results have been recorded also for sleep quality and anxiety. Following, a double-blind crossover clinical trial was carried out to evaluate probiotics ability on mood and sleep quality during Covid-19 pandemic. A total of 33 volunteers were randomly assigned into two groups, with an inverted administration of KeepCalm (4B CFU/day) and placebo for 30 days each, with a 4-week intermediate wash-out. The efficacy on stress response, in terms of mood and sleep quality, were assessed using The Pittsburgh Sleep Quality Index (PSQI) and the Profile of Mood State (POMS) questionnaires. Results showed that both questionnaires reported a significant lower score after 30 days, while the placebo reported a higher score reflecting a worsening of mood and sleep quality.  KeepCalm’s latest clinical trial  investigate another model of mood impairment: a RDBPC clinical trial to evaluate the effect of the probiotic complex on 200 healthy women after delivery, in terms of modulation of mother’s mood and assess the quality of breastfeeding through the reduction of baby’s crying and mastitis occurrence. Results demonstrated a very strong support concerning new-mothers mood as well as breastfeeding confidence.