HappyBelly is a probiotic complex by SynBalance, specifically designed to support children’s gastrointestinal health.
HappyBelly has been clinically tested in a randomized double blind placebo controlled clinical trial.  100 IBS-C subjects were randomly divided in two groups 50 supplemented with a daily dose of 4B/ day for 60 days + 30 days of follow-up and 50 supplemented with placebo. Stool samples have been collected in order to determine the gastrointestinal colonization during the administration period and also in the follow-up; subjects also fulfilled a questionnaire to determine IBS-C symptoms improvement.
Beneficial positive effect demonstrated after only 10 days the efficacy of HappyBelly 4B CFU/day composed by L. reuteri PBS072 and L. acidophilus PBS066.  Result showed the colonization and persistance in the gastrointestinal tract during the trial and even after 30 days from the last intake; reduction of IBS-C symptoms quickly and steadily. 

Scientific reference(s)

Reference: Mezzasalma, Valerio, et al. ""A randomized, double-blind, placebo-controlled trial: the efficacy of multispecies probiotic supplementation in alleviating symptoms of irritable bowel syndrome associated with constipation."" BioMed research international 2016 (2016).
Antimicrobial activity against a wide range of GI patoghens Presti, I., et al. ""Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect."" Applied microbiology and biotechnology 99.13 (2015): 5613-5626.

Additional info

Therapeutical area(s)

Gastrointestinal tract


Constipation · IBS



Dosage form



4 billion(s)
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